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Inhibition of the mechanistic target of rapamycin induces ...

Tuberous sclerosis complex (TSC) is a genetic disorder that cause tumors to form in many organs. These lesions may lead to epilepsy, autism, developmental delay, renal, and pulmonary failure. Loss of function mutations in TSC1 and TSC2 genes by aberrant activation of the mechanistic target of rapamycin (mTORC1) signaling pathway are the known causes of TSC.

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1. Introduction. In the last two decades, the supramolecular chemistry of inorganic compounds has attracted increasing interest because of their fascinating structures and their potential applications in various fields such as catalysis [], gas storage [], and molecular recognition [3,4].It is now well-established that the manner in which molecular building blocks are arranged within ...

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1 INTRODUCTION. A pseudovirus is a recombinant viral particle with its core/backbone and envelope proteins derived from different viruses 1; moreover, the genes inside the pseudovirus are usually altered or modified so that they are unable to produce the surface protein on their own.As such, an additional plasmid or stable cell line expressing the surface proteins is needed to make the ...

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An Extension Study in Participants With Moderate to Severe ...

Winthrop KL, Bingham CO 3rd, Komocsar WJ, Bradley J, Issa M, Klar R, Kartman CE. Evaluation of pneumococcal and tetanus vaccine responses in patients with rheumatoid arthritis receiving baricitinib: results from a long-term extension trial substudy. Arthritis Res Ther. 2019 Apr 18;21(1):102. doi: 10.1186/s13075-019-1883-1.

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Kelly stepped into this sweet spot with a forgone conclusion. He was a fantastic B3 player. Had his own rig and a trailer. When it was his time to bring it, he could really bring it. And he had Moog Synthesizer too. Now THAT was different. He could make it sound like horns way before Toto. Jerry Jeff loved everything about it and wanted Kelly in the band.

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Diabetic ketoacidosis in adult patients: an audit of ...

Melissa H. Lee, Department of Endocrinology and Diabetes, St Vincent's Hospital Melbourne, 41 Victoria Parade, Fitzroy, Vic. 3065, Australia. Email: melissa.lee@svha.org.au Search for more papers by this author

MGH Center for Systems Biology :: Mouse Imaging ...

King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng Jr RP, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R . IRF3 and type I interferons fuel a fatal response to myocardial infarction. Nature Med. 2017;23(12):1481-1487 - PMID: 29106401 - PMCID: PMC6477926 - DOI: 10.1038/nm.4428. Miller MA, Weissleder R ...

Roles of IFN-γ in tumor progression and regression: a ...

Interferon-γ (IFN-γ) plays a key role in activation of cellular immunity and subsequently, stimulation of antitumor immune-response. Based on its cytostatic, pro-apoptotic and antiproliferative functions, IFN-γ is considered potentially useful for adjuvant immunotherapy for different types of cancer. Moreover, it IFN-γ may inhibit angiogenesis in tumor tissue, induce regulatory T-cell ...

Modelling of plug-in hybrid electric vehicle (PHEV) with ...

1. Introduction. In the present day, mostly petrol cars and diesel cars are using because due to the initial cost of these cars is low. Here the initial cost may be low but the maintenance cost is more as the fuel cost is going on increasing, and also pollution is more with these vehicles .The main reason that we have to move into electric vehicles is to reduce the maintenance cost and ...

VARS2 - Wikipedia

Valyl-tRNA synthetase 2, mitochondrial is a protein that in humans is encoded by the VARS2 gene.. Function. This gene encodes a mitochondrial aminoacyl-tRNA synthetase, which catalyzes the attachment of valine to tRNA(Val) for mitochondrial translation. Mutations in this gene cause combined oxidative phosphorylation deficiency-20, and are also associated with early-onset mitochondrial ...

List of minor planets: 18001–19000 - Wikipedia

The following is a partial list of minor planets, running from minor-planet number 18001 through 19000, inclusive.A detailed description of the table's columns and used data sources are given on the main page. The main index provides an overview of the entire minor-planet catalog. Also see the summary list of all named bodies in numerical and alphabetical order, as well as the corresponding ...

Neuronal Circuits in Barrel Cortex for Whisker Sensory ...

Helmstaedter M, Briggman KL, Turaga SC, Jain V, Seung HS, Denk W. Connectomic reconstruction of the inner plexiform layer in the mouse retina . [Correction in Nature 514: 394, 2014.]

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Total hip and knee arthroplasty (THA/TKA) have been widely performed since the 1970s. In 2009 over a million of THA and TKA were carried out in the United States [].Osteoarthritis (OA) is the main clinical indication for which these procedures are performed [].Due to the ageing society as well as the obesity epidemic, the prevalence of OA is increasing [].

Favorable prognostic value of SOCS2 and IGF-I in breast cancer

Favre H, Benhamou A, Finidori J, Kelly PA, Edery M. Dual effects of suppressor of cytokine signaling (SOCS-2) on growth hormone signal transduction. FEBS Lett. 1999; 453:63–66. doi: 10.1016/S0014-5793(99)00681-X.

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Waldo KL, Kumiski DH, Wallis KT, Stadt HA, Hutson MR, Platt DH, et al. Conotruncal myocardium arises from a secondary heart field. Development. 2001; 128:3179–3188. 7. Buckingham M, Meilhac S, Zaffran S. Building the mammalian heart from two sources of myocardial cells. Nat Rev Genet. 2005; 6:826–835. 8. Vincent SD, Buckingham ME. How to make a heart: the origin and regulation of cardiac ...

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Family names that begin with the letter K. There are a total of 16,025,836 people from 125 countries with surnames that start with the letter K.Click a link below that corresponds to the first three letters of the last name you are searching for.

Flexible electronics under strain: a review of mechanical ...

Flexible electronics incorporate all the functional attributes of conventional rigid electronics in formats that have been altered to survive mechanical deformations. Understanding the evolution of device performance during bending, stretching, or other mechanical cycling is, therefore, fundamental to research efforts in this area.

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Members – Deshler, Ohio, Chamber of Commerce

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Connective Tissue Disease-Related Interstitial Lung ...

Interstitial lung disease is a common pulmonary manifestation of connective tissue diseases and results in significant morbidity and mortality. Although all connective tissue diseases are linked by underlying autoimmunity, there is significant variability in the presentation and clinical course of interstitial lung disease associated with the different types of connective tissue diseases.

Over‐expression of platelet‐derived growth factor in human ...

Darren J. Kelly Search for other works by this author on: Oxford Academic. PubMed. Google Scholar. ... 41 Victoria Parade, Fitzroy, Victoria 3065 Australia. Email: rlangham@medstv.unimelb.edu.au. References. 1. Kelly DJ, Gilbert RE, Cox AJ, Soulis T, Jerums G, Cooper ME. Aminoguanidine ameliorates overexpression of prosclerotic growth factors and collagen deposition in experimental diabetic ...

Adressbuch für Berlin und seine Vororte (Public Domain ...

Adressbuch für Berlin und seine Vororte (Public Domain) Issue 1899 (Public Domain)

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Clinical Ophthalmology - Dove Press Open Access Publisher

Ah-See KL, Blaikie A, Boyle N, Foulds J, Wheeldon C, Wilson P, Styles C, Sutherland S, Sanders R . Clinical Ophthalmology 2021, 15:289-297 Published Date: 25 January 2021. Original Research. Ten-Year Real-World Outcomes of Anti-Vascular Endothelial Growth Factor Therapy in Neovascular Age-Related Macular Degeneration. Cheema MR, DaCosta J, Talks J. Clinical Ophthalmology 2021, 15:279-287 ...

Thieme E-Journals - Synthesis / Abstract

Abstract. We have developed a versatile and efficient method for copper-catalyzed synthesis of both 2-amino-4(3H)-quinazolinone and 2-aminoquinazoline derivatives.The protocol uses readily available substituted 2-halobenzoic acids, 2-bromobenzaldehyde, 2-bromophenyl ketones and guanidines as the starting materials, inexpensive copper(I) iodide as the catalyst, and the method has important ...

Labor und Diagnose 2020 | Kapitel 03: Kohlenhydratstoffwechsel

Kelly TN, Bazzano LA, Fonseca VA, Theti TK, Reynolds K, He J. Systematic review: glucose control and cardiovascular disease in type 2 diabetes. Ann Intern Med 2009; 151: 394–403. 71. Capes SE, Hunt D, Malmberg K, et al. Stress hyperglycemia and increased risk of death after myocardial infarction in patients with and without diabetes: A systematic overview. Lancet 2000; 355; 733–8. 72 ...

UASOM Faculty Profiles

Forero A, Li Y, Chen D, Grizzle WE, Updike KL, Merz ND, Downs-Kelly E, Burwell TC, Vaklavas C, Buchsbaum DJ, Myers RM, LoBuglio AF, Varley KE: Expression of the MHC Class II Pathway in Triple-Negative Breast Cancer Tumor Cells Is Associated with a Good Prognosis and Infiltrating Lymphocytes. Cancer Immunol Res 4:390-399, 2016. 26980599

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The Environmental Estrogen Bisphenol A Inhibits Estradiol ...

Howdeshell KL, Peterman PH, Judy BM, Taylor JA, Orazio CE, Ruhlen RL et al.. 2003. ... Endocrinology 145:3065-3073 15033916. Crossref, Medline, Google Scholar; Quesada I, Fuentes E, Viso-Leon MC, Soria B, Ripoll C, Nadal A. 2002. Low doses of the endocrine disruptor bisphenol-A and the native hormone 17beta-estradiol rapidly activate transcription factor CREB. FASEB J 16:1671-1673 12207000 ...

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Staff Profile - Engineering, School of - Newcastle University

Environmental Science and Technology 2017, 51(5), 3065-3073. Martin TJ, Goodhead AK, Acharya K, Head IM, Snape JR, Davenport RJ. High Throughput Biodegradation-Screening Test to Prioritize and Evaluate Chemical Biodegradability. Environmental Science and Technology 2017, 51(12), 7236-7244. Bushnaf KM, Mangse G, Meynet P, Davenport RJ, Cirpka OA, Werner D. Mechanisms of Distinct Activated ...

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Staff | Geography | University of Exeter

Adger WN, Lorenzoni I, O'Brien KL (2009). Adapting to Climate Change: Thresholds, Values, Governance., Cambridge Univ Press. Abstract ... (3065), 26-27. Cinnamon J, Jones SK, Adger WN (2016). Evidence and future potential of mobile phone data for disease disaster management. Geoforum, 75, 253-264. Abstract. Full text. Nicholls RJ, Hutton CW, Lázár AN, Allan A, Adger WN, Adams H, Wolf J ...

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